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KMID : 1142120150170020138
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Journal of Stroke
2015 Volume.17 No. 2 p.138 ~ p.143
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Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis
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Kumar Amit
Prasad Manya
Kumar Pradeep
Yadav Arun Kumar
Pandit Awadh Kishor
Kathuria Prachi
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Abstract
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Background and Purpose: The purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (β2AR) polymorphism and Ischemic stroke.
Methods: Published case control studies on association between β2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2.
Results: A total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of β2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of β2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81).
Conclusions: The present meta-analysis suggests that Gln27Glu polymorphism of β2AR gene is associated with increased risk for ischemic stroke.
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KEYWORD
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β2-adrenergic receptor gene, β2AR, Ischemic stroke, Cerebral infarction, Polymorphism, Meta-analysis
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